Macrocyclic polyenynes: a stereoselective route to vinyl-ether-containing skipped diene systems.
نویسندگان
چکیده
The stereoselective synthesis of a challenging macrocyclic polyene scaffold, containing a sensitive vinyl ether motif, has been accomplished using O,C-dilithiation/selective C-alkylation, Pd-catalysed etherification and Wittig reactions as key steps. An end-game macrocyclisation strategy employed a regio- and stereoselective Stille cross-coupling using Pd(Br)(N-Succ)(AsPh3)2 (AsCat) as the precatalyst.
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عنوان ژورنال:
- Chemical communications
دوره 51 38 شماره
صفحات -
تاریخ انتشار 2015